ORAL PRESENTATIONS 

Information for Presenters 

• Each Oral presentation will be 10 minutes long plus 5 minutes for discussion
• A detailed presentation schedule will be posted on the Congress website
• A computer and full powerpoint set up will be provided. Presenters must bring their presentation file on a USB stick or CD
• Presentations will be loaded on the onsite computer prior to the presentation. Details on the time and place to meet to load your presentation will be provided to you when you register at the conference  

Update: September 14, 2009 

Late Abstracts 

The Congress Organizers have advised that new abstracts with late-breaking information of particular interest can be submitted to the Congress for poster presentation. Contact us for more information.  

MONDAY OCTOBER 5, 2009
Oral Session 2.1, 0900-1000
Room 1
0900-0915	O2111 In vivo CYP3A4/5 activity is significantly higher in tacrolimus treated as compared to cyclosporine treated renal transplant recipients three months after transplantation. Hylke de Jonge1, Henriette de Loor1, Kristin Verbeke2, Yves Vanrenterghem1, Dirk R Kuypers1. 1Dept. of Nephrology and Renal Transplantation and 2Laboratory of Digestion and Absorption, University Hospitals Leuven, Leuven, Belgium.
0915-0930	O2112 DLIF is Cytotoxic to Breast Cancer Cells: A Novel Mechanism for Prevention of Breast Malignancies. Mohammad Al-Ghoul, Edward P. Womack Jr, and Roland Valdes, Jr. Department of Pathology and Laboratory Medicine, University of Louisville.
0930-0945	O2113 The Necessity of Therapeutic Drug Monitoring of Vancomycin in Clinical Use: A Systematic Review ZHANG Chao1,2, ZHAI Suodi1,2, LIU Fang1,2. 1Department of Pharmacy, Peking University Third Hospital, Beijing, China; 2Therapeutic Drug Monitoring & Clinical Toxicology Center, Peking University, Beijing, China.
0945-1000	O2114 The effect of high dose methylprednisolone therapy on in vivo CYP3A4/5 activity and calcineurin inhibitor pharmacokinetics in renal transplant recipients: a pilot study. Hylke de Jonge1, Henriette de Loor1, Kristin Verbeke2, Yves Vanrenterghem1, Dirk R Kuypers1. 1Dept. of Nephrology and Renal Transplantation and 2Laboratory of Digestion and Absorption, University Hospitals Leuven, Leuven, Belgium.
Room 2
0900-0915	O2121 Ten Years of Experience with the International Inter-laboratory Quality Control Program for Measurement of Antiretroviral Drugs David Burger, Marga Teulen, Jaco Eerland, Anneke Harteveld, Rob Aarnoutse, Daan Touw. Radboud University Nijmegen Medical Center & KKGT
0915-0930	O2122 Validation and clinical application of a high performance liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the quantitative determination of 10 antiretrovirals in human peripheral blood mononuclear cells. L.Elens1, S.Veriter 1, JC.Yombi2, V.Di Fazio 3, R.Vanbinst 3, D.Lison1, P.Wallemacq3, B.Vandercam2, V.Haufroid 1,3.1 Industrial Toxicology and Occupational Medicine Unit, Université catholique de Louvain, Brussels, Belgium. 2 Department of Internal Medicine, Unit of Infectious Diseases, St-Luc University Hospital, Brussels, Belgium. 3Clinical Chemistry Department, St-Luc University Hospital, Brussels, Belgium.
0930-0945	O2123 Comparison of the ARK immunoassay to the Seradyn fluorescence polarization immunoassay for measurement of serum topiramate. Christine LH Snozek, Lisa A Rollins, Paul W Peterson, and Loralie J Langman. Toxicology and Drug Monitoring Laboratory, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA 55904.
0945-1000	O2124 Topiramate Determination in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry: Application to Therapeutic Drug Monitoring Kamal M. Matar, Faculty of Pharmacy, Kuwait University
Room 3
0900-0915	O2131 Dose proportionality of mycophenolate mofetil in renal transplant recipients Brenda CM de Winter1, PharmD; Teun van Gelder1,2, MD, PhD; Ferdi Sombogaard1, PharmD; Reinier M van Hest1, PharmD, PhD; Ron AA Mathot1, PharmD, PhD. 1Department of Hospital Pharmacy, Clinical Pharmacology Unit, 2Department of Internal Medicine, Renal Transplant Unit, Erasmus University Medical Center, Rotterdam, The Netherlands.
0915-0930	O2132 Mycophenolate pharmacodynamics is altered with time since transplantation. Sara Bremer,1,2 Nils Tore Vethe,1,2 Helge Rootwelt,1,2 Pål Foyn Jørgensen,3 Jean Stenstrøm,4 Hallvard Holdaas,4 Karsten Midtvedt4 and Stein Bergan1,2,5. From the 1Dept. of Medical Biochemistry, Rikshospitalet University Hospital, Oslo; 2Institute of Clinical Biochemistry, University of Oslo; 3Section for Transplant Surgery, Rikshospitalet University Hospital, Oslo; 4Dept. of Medicine, Rikshospitalet University Hospital, Oslo; 5School of Pharmacy, University of Oslo, Norway
0930-0945	O2133 Tacrolimus levels in peripheral blood mononuclear cells are associated with histological staging of rejection in the early phase after liver transplantation. A. Capron1, J. Lerut2, M. Mourad2, E. Bonaccorsi-Riani2, D. Latinne3, V. Haufroid1, P. Wallemacq1. 1Department of Clinical Chemistry, 2Department of Abdominal Transplantation, 3Department of Immunohaematology. Cliniques Universitaires St Luc, Université catholique de Louvain, Brussels, Belgium.
0945-1000	O2134 Pharmacokinetics of omeprazole multi-unit pellet system (Losec MUPS®) vs. extemporaneous bicarbonate formulation in patients with cerebral palsy: a HILIC-MS/MS method for the quantification of omeprazole and lansoprazole De Smet J.a, Boussery K.a, Van Winckel M.b, De Cock P.c, De Paepe P.d and Van Bocxlaer J.a; aLaboratory of Medical Biochemistry and Clinical Analysis, bDepartment Paediatric Gastroenterology, cDepartment Pharmacy, dHeymans Institute of Pharmacology; Ghent University, Gent, Belgium.
Oral Session 2.2, 1030-1130
Room 1
1030-1045	O2211 Whole Blood/Plasma Ratios in Ten Chronic Cannabis Users after Frequent Oral THC Administration Erin L. Karschner1, David M. Schwope1, Eugene W. Schwilke1, David A. Gorelick2, Robert S. Goodwin1, Ross H. Lowe1, Deanna L. Kelly3 and Marilyn A. Huestis1. 1Chemistry and Drug Metabolism and 2Office of the Scientific Director, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, 3Maryland Psychiatric Research Center, University of Maryland School of Medicine, Catonsville, USA.
1045-1100	O2212 Enantioselectivity in the Methylation of Catecholic Phase-I Metabolites of MDMA (Ecstasy), MDEA (Eve), and MBDB (Eden) Catalyzed by Soluble or Membrane-bound Catechol-O-Methyltransferase. Markus R. Meyer and Hans H. Maurer. Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, Homburg, Germany
1100-1115	O2213 MDMA Phase II Metabolites R- and S-4-Hydroxy-3-methoxy-methamphetamine-O- glucuronides: Synthesis using Rat Liver Microsomes, Isolation and Clean-up Andrea E. Schwaningera, Markus R. Meyera, Josef Zappb, and Hans H. Maurera Department of Experimental and Clinical Toxicology, Saarland University, D-66421 Homburg (Saar), Germany; bDepartment of Pharmacy, Pharmaceutical Biology, Saarland University, D-66123 Saarbruecken, Germany
1115-1130	O2214 Placenta for monitoring in utero drug exposure to buprenorphine and correlation with neonatal outcomes Marta Concheiro1, Hendree E Jones2, Rolley E Johnson2, Diaa M Shakleya1, Marilyn A Huestis1 . 1Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 2Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
Room 2
1030-1045	O2221 Proving the Analytical Quality of Immunosuppressant TDM by Using Qualifier Ion Pairs Christoph Seger, Andreas Falkner, Hartwig Pfisterer, Andrea Griesmacher Division of Mass Spectrometry and Chromatography, Institute of Medical and Chemical Laboratory Diagnostics (ZIMCL), University Hospital Innsbruck, Austria.
1045-1100	O2222 5-Fluoruracil plasma determination: A benchtop platform for an automated immunoassay. S. J. Salamone1, J. B. Courtney1, R. L. Harney1, 1Saladax Biomedical Inc., Bethlehem, PA, USA
1100-1115	O2223 Monitoring Maternal Methamphetamine Use by Self-Report and Meconium Toxicology in The Infant Development, Environment and Lifestyle Study Teresa R. Gray, Tamsin L. Kelly, Linda L. LaGasse, Lynne M. Smith, Chris Derauf, William F. Haning, Penny Grant, Rizwan Shah, Amelia M. Arria, Arthur Strauss, Barry M. Lester, Marilyn A. Huestis. IDEAL Community Research Network, Providence, RI
1115-1130	O2224 Assessment of Co-Medication Interference in a Routine Immunosuppressant HPLC-MS/MS Assay Christoph Seger, Andrea Griesmacher. Division of Mass Spectrometry and Chromatography, Institute of Medical and Chemical Laboratory Diagnostics (ZIMCL), University Hospital Innsbruck, Austria.
Room 3
1030-1045	O2231 Limited sampling strategies drawn within three hours postdose for estimation of MPA AUC0-12 after EC-MPS are unsuitable for use in clinical practice Brenda CM de Winter1, Teun van Gelder1, Ron AA Mathot1, Klemens Budde2, Helio Tedesco-Silva3, Luuk Hilbrands4, Reinier M van Hest1. 1Erasmus MC, Rotterdam, The Netherlands; 2Charité, Berlin, Germany; 3Hospital do Rim e Hipertensao, Sao Paulo, Brazil; 4Radboud MC, Nijmegen, The Netherlands.
1045-1100	O2232 Non-invasive assessment of renal function via transdermal reverse iontophoresis of iohexol: A pilot study. 1A. Djabri, 2W. van’t Hoff; 2P.Brock, 3I.C.K. Wong; 1R.H. Guy; 1M.B. Delgado-Charro 1 Pharmacy and Pharmacology, University of Bath, UK, 2Great Ormond Street Hospital, London, UK; 3Centre for Paediatric Pharmacy Research, The School of Pharmacy, University of London,UK.
1100-1115	O2233 Disposition of Fluoxetine and Norfluoxetine Racemates and Enantiomers Across Childbearing: Impact on Dose. D.KY. Sit, J.M. Perel, J.C. Helsel, K.L. Wisner. Univ of Pittsburgh School of Medicine, Pittsburgh, PA
1115-1130	O2234 Limited sampling strategies for mycophenolic acid in patients with autoimmune disease Brenda CM de Winter1, Irmgard Neumann2, Teun van Gelder1, Reinier M van Hest1, Ron AA Mathot1. 1 Erasmus University Medical Center, Rotterdam, The Netherlands; 2Wilhelminenspital, Vienna, Austria.
TUESDAY OCTOBER 6, 2009
Oral Session 3.1, 0900-1000
Room 1
0915-0930	O3111 New tools for the pharmacodynamic monitoring of immunosuppressive drugs in pediatric kidney, heart and liver transplant patients. Lapeyraque AL1,2,3, Durrieu V2,3, Phan V2, Alvarez F2,3, Raboisson MJ2, Haddad E2,3,4, Brito RM 2, Lajeunesse J4, Théorêt Y1,3,5, Le Deist F 1,2,3,4. 1Unité de Pharmacologie Clinique, 2Département de pédiatrie, 3Centre de recherche, et 4 Dépt de microbiologie et immunologie, CHU Sainte Justine, et 5Département de Pharmacologie, 2,4,5Université de Montréal, Montréal Qc, Canada
0930-0945	O3112 Pharmacokinetic-pharmacodynamic modeling of inosine monophosphate dehydrogenase activity in mycophenolate mofetil treated renal transplant patients Ron AA Mathot1 PharmD PhD, Ferdi Sombogaard1 PharmD, Ron van Schaik2 PhD, WillemWeimar3 MD PhD, Teun van Gelder1,3 MD PhD. Depts of 1Hospital Pharmacy, 2Clinical Chemistry and 3 Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
0945-1000	O3112 Biomarkers of the State of Immunosuppression in Stable Liver Transplant Patients Following Withdrawal of Immunosuppressant Treatment Protocols O. Millán1,3, A. Sánchez-Fueyo2,3, C. Benitez2; A. Rimola2,3, D. Guillen1,M. Brunet1,3 1Pharmacology and Toxicology Laboratory (CDB) ,2Digestive and Metabolic Diseases Clinic Institute,3CIBERehd, IDIBAPS, Hospital Clínic Barcelona. Universitat de Barcelona.
Room 2
0915-0930	O3121 CYP3A5 and ABCB1 polymorphisms influence tacrolimus peripheral blood mononuclear cells concentration in the early phase after renal transplantation. A. Capron1, M. Mourad2, V. Haufroid1, P. Wallemacq1. 1Department of Clinical Chemistry, 2Department of Abdominal Transplantation. Cliniques Universitaires St Luc, Université catholique de Louvain, Brussels, Belgium.
0930-0945	O3122 ABCC2 4544G>A polymorphism is associated with Lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients. Elens L1, Yombi JC2, Lison D1, Wallemacq P3, Vandercam B2, Haufroid V1,3. 1 Industrial Toxicology and Occupational Medicine Unit, Université catholique de Louvain, Brussels, Belgium. 2 Department of Internal Medicine, Unit of Infectious Diseases, St-Luc University Hospital, Brussels, Belgium. 3 Clinical Chemistry Department, St-Luc University Hospital, Brussels, Belgium.
0945-1000	O3123 Effect of gene polymorphisms on pharmacokinetics of calcineurin inhibitors in Indian renal transplant recipients. Ashavaid TF, Raje HS, Shalia K, Shah BV. P.D. Hinduja National Hospital and Medical Research Center, Mumbai, India.
Room 3
0915-0930	O3131 Monitoring Anticonvulsant-Induced Hypersensitivity Syndrome Simon Nigen MD, Sandra R. Knowles Pharm. D., Neil H. Shear MD, Lori E. Shapiro MD, Manuela G. Neuman Ph.D. Service de Dermatologie, Département de Médecine, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, Québec; Divisions of Dermatology, Clinical Pharmacology and Drug Safety Clinic, Sunnybrook Health Sciences Centre, In Vitro Drug Safety and Biotechnology Laboratory and Departments of Medicine and Pharmacology, University of Toronto, Toronto, Ontario, Canada.
0930-0945	O3132 Detection of the CYP2C19*17 Allele with Real Time PCR Julia Stäker , Werner Steimer. Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, TU-München. Ismaninger Str. 22, 81675 München, Germany
0945-1000	O3133 UGT and ABCB1 polymorphisms may be associated with leucopenia following Mycophenolic acid therapy in pediatric kidney transplant recipients Tsuyoshi Fukuda, Ph.D. 1, Susan E. Prausa, Pharm.D. 1, 2, Denise Maseck, R.N. 1, David Hooper, M.D. 3, Chunyan Liu, M.S.5, Kejian Zhang, M.D., MBA.4, Todd G. Nick Ph.D. 5, Jens Goebel, M.D. 3 and Alexander A.Vinks, Pharm.D. Ph.D.1. 1Divisions of Clinical Pharmacology and Pediatric Pharmacology Research Unit, 2Pharmacy, 3Nephrology and Hypertension Division, 4Human Genetics, 5Biostatistics and Epidemiology, Cincinnati Children’s Hospital Medical Center& Department of Pediatrics, Collage of Medicine, University of Cincinnati, Cincinnati, OH (USA)
Oral Session 3.2, 1030-1130
Room 1
1030-1045	O3211 Therapeutic Drug Monitoring of Leflunomide (A77 1726) as an Immunosuppressive (IS) Alternative in Thoracic Transplantation Lefeuvre S1,3, Faiz I1, Guillemain R2, Chevalier P2, Boussaud V2, Amrein C2, Le Beller C1, Billaud EM1,3 . Department of 1Pharmacology, 2Cardiovascular Surgery, Hôpital Européen G Pompidou, 3Paris Descartes University
1045-1100	O3212 Development of an assay for tobramycin therapeutic drug monitoring using dried blood spots D.J. Touw1,2, R. van Rossen1, J. de Vries2, S.M. Ockhorst-Boon2, H.G.M. Heijerman2. 1Apotheek Haagse Ziekenhuizen and 2Centre for adult cystic fibrosis patients, Haga Hospital, The Hague, The Netherlands.
1100-1115	O3213 Alternate Sampling Strategy for TDM of Immunosuppressants: Augmenting Transplant Monitoring Pleasant F. Hooper1, Thomas D. Dreesen1, Douglas P. Slackey2, Brian G. Keevil3, Sander S. Florman4 1 TMS BioScience, New Orleans, LA; 2 Tulane University Department of Surgery, New Orleans, LA; 3 University Hospital of South Manchester; 4Tulane Abdominal Transplant Institute
1115-1130	O3214 Therapeutic drug monitoring (TDM) of the antifungal posaconazole (PSZ) in cystic fibrosis (CF) lung transplant (LTx) patients Berge M1, Chevalier P2, Lefeuvre S1,4, Amrein C2, Boussaud V2, Guillemain R2, Dannaoui E3,4, Billaud EM1,4 . Department of 1Pharmacology, 2Cardiovascular Surgery, 3Mycology, Hôpital Européen Georges Pompidou, 4Paris Descartes University, France
Room 2
1030-1045	O3221 Time of drug administration, genetic polymorphism and analytical method influence tacrolimus pharmacokinetics: a population pharmacokinetic approach FT Musuamba1, M Mourad2, V Haufroid1, RK Verbeeck3 and P Wallemacq1 1 Clinical chemistry department, UCL, Brussels, 2 Division of Abdominal Transplantation, Cliniques universitaires St-Luc, 3 School of Pharmacy, UCL, Brussels, Belgium
1045-1100	O3222 Pharmacokinetic tools for, and clinical findings in favour of, the therapeutic drug monitoring of mycophenolate mofetil in children with idiopathic nephrotic syndrome. F. Saint-Marcoux(1), B. Ranchin(2), V.Guigonis(3), JB Palcoux(4), F.Bouissou(5), J. Harambat(6), F. Broux(7), E. Berard(8), P. Marquet(1). (1) INSERM UMR-S850, Univ Limoges, CHU Limoges, France; Dept of Pediatry of: (2)CHU Lyon, France; (3)CHU Limoges, France; (4)CHU Clermont-Ferrand, France; (5)CHU Toulouse, France; (6)CHU Bordeaux, France; (7)CHU Rouen, France;, (8) CHU Nice, France.
1100-1115	O3223 Determination of Colistin in Plasma and Bronchoalveolar Lavage of Critically Ill Patients Using HPLC M. Cusato1, R. Imberti2, P. Villani1, L. Carnevale2, G. Iotti2, M. Langer3, M. Regazzi1 1Laboratory of Clinical Pharmacokinetics, Foundation IRCCS Policlinico San Matteo, Pavia; 2Department of Anesthesiology and CCM, Foundation IRCCS Policlinico San Matteo, Pavia; 3Department of Anesthesiology and CCM, Istituto Nazionale dei Tumori IRCCS, Milano
1115-1130	O3224 Development and validation of multiple linear regression formulas and a Bayesian estimator for mycophenolic acid long term therapeutic drug monitoring F Musuamba1, A Rousseau2, JL Bosmans3, JJ Senessael4, J Cumps1,P Marquet2, RK Verbeeck1 and P Wallemacq1. 1 Department of clinical chemistry, Cliniques Universitaires St Luc, and School of Pharmacy, UCL, Brussels, Belgium, 2 INSERM U850, CHU Limoges, Université de Limoges, Limoges, France, 3 Department of Nephrology and Hypertension, University, Hospital, University of Antwerp, Edegem, Belgium, 4Renal Unit, Academic Hospital, UZ-Brussels, Belgium
Room 3
1030-1045	O3231 Influence of CYP3A5*3 Genetic Polymorphisms On Cyclosporine Pharmaco- kinetics and the Acute Rejection in Renal Transplantation: A Meta-analysis Hui-Lin Tang, Sui-Di Zhai, Ting Zhang, Yong-Fang Hu*. Peking University Third Hospital, Therapeutic Drug Monitoring and Clinical Toxicology Center of Peking University, Beijing, People’s Republic of China
1045-1100	O3232 The hepatic Organic Anion Transporting Polypeptides (OATP) uptake transporters are involved in mycophenolic acid pharmacokinetics: effect of major genetic variants on drug exposure in kidney transplants. Picard N1, Yee SW2, Woillard J-B1, Lebranchu Y3, Le Meur Y4, Giacomini KM2 and Marquet P1. 1Inserm UMR-S850, Limoges France;CHU Limoges, France; Univ Limoges, France; 2Univ Calif San Francisco, Dept Biopharmaceutical Sciences, San Francisco, CA 94143 USA; 3CHU Tours, Dept Nephrology and Clinical Immunology, Tours, France;4CHU Brest, Dept of Nephrology, Brest, France.
1100-1115	O3233 Association between polygenetic variations and warfarin dose in Chinese-Han Patients Ting Zhanga,b, Sui-Di Zhaia, Shao-Fang Zhenga, Fang Xuc, Hui-Lin Tanga, Yong-Fang Hua*. aPeking University Third Hospital, Therapeutic Drug Monitoring and Clinical Toxicology Center of Peking University, Beijing, bDept. of Pharmacy Administration and Clinical Pharmacy, Peking University; Beijing, cShenzhen Food and Drug Administration, Shenzhen, Guangdong, People’s Republic of China
1115-1130	O3234 Population Pharmacokinetics of Tacrolimus in Renal Transplant Patients Hua-ming Wanga,b, Suo-Di Zhaia , Juan Xieb, Yong-fang Hua*. aPeking University Third Hospital, Therapeutic Drug Monitoring and Clinical Toxicology Center of Peking University, Beijing, bGuiyang Medical University, Guyang Beijing, People’s Republic of China.
WEDNESDAY OCTOBER 7, 2009
Oral Session 4.1, 0900-1000
Room 1
0900-0915	O4111 Topotecan pharmacokinetics after periocular or intravitreous administration: an alternative for retinoblastoma chemotherapy. Guillermo F Bramuglia1, Emiliano Buitrago1, Angel Montero Carcaboso1, Adriana Fandiño2, Eduardo Lagomarsino2, Myriam Guitter2, Adriana Rose2, Julio Manzitti2, David H Abramson3, Paula Shaiquevich2 and Guillermo L Chantada2. 1Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires; 2Hospital JP Garrahan, Buenos Aires, Argentina, 3Memorial Sloan Kettering Cancer Center, New York, USA.
0915-0930	O4112 Towards a prospective screening test for fluoropyrimidine toxicity: preliminary pharmacokinetic data for thymine and dihydrothymine in healthy male adults. Bruce Charles1, Rani George1,2, Ross Norris1,2,3, Catherine Shannon4, Andrew Cameron4, Ken Musgrave4, John Duley1,5. 1School of Pharmacy, The University of Queensland, Brisbane; 2Australian Centre for Paediatric Pharmacokinetics, Mater Health Services, Brisbane; 3School of Pharmacy, Griffith University, City of Gold Coast; 4Oncology Division, Mater Health Services, Brisbane; 5Pathology Department, Mater Pharmacy Services, Brisbane, Queensland, Australia.
0930-0945	O4113 Pharmacokinetic voriconazole monitoring in preventing aspergillosis in immunocompromised pediatric patients with hematologic malignancies M. Cusato1, G. Giorgiani2, P. Villani1, A. Bertaina2, M.Broglia1, M. Regazzi1, F. Locatelli2 . 1Laboratory of Clinical Pharmacokinetics and 2 Department of Pediatrics, Pediatric Hematology Unit, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
0945-1000	O4114 Explaining the differences in clearance of mycophenolic acid between renal transplant recipients, heamatopoietic stemcell transplant recipients and patients with autoimmune disease Brenda CM de Winter1; Ron AA Mathot1; Ferdi Sombogaard1; Irmgard Neumann2; Reinier M van Hest1; Teun van Gelder1. 1Erasmus University Medical Center, Rotterdam, The Netherlands; 3Wilhelminenspital, Vienna, Austria.
Room 2
0900-0915	O4121 Population pharmacokinetics of escitalopram in overdose and the effect of charcoal van Gorp F1,2, Duffull SB3, Hackett LP4, Isbister GK1. 1Department of Clinical Toxicology, Calvary Mater Newcastle,Australia; 2 Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands; 3 School of Pharmacy, University of Otago; 4 PathWest Laboratory Medicine WA, Perth, Australia
0915-0930	O4122 SOME PSYCHOTROPIC EFFECTS OF KOLA NUT (COLA NITIDA) EXTRACT ON ADULT WISTAR RATS Abiodun Ayoka1, Adeyemi Ogunleye2 ,Olusegun Babalola3, Bosun Banjoko 4 1Dept of physiology, 2Dept of Medical Lab.Science, Ambrose Alli University, Ekpoma, Nigeria, 3Dept of Chemical Pathology,4Dept of Biochemistry, 1,3,4Obafemi Awolowo University, Ile-Ife, Nigeria
0930-0945	O4123 Quantification of daptomycin with LC-MS/MS in plasma samples of patients undergoing continuous veno-venous hemodiafiltration Rentsch Katharina M.1, Gutteck-Amsler Ursula1, Corti Natascia2, Rudiger Alain3, Maggiorini Marco3 1Institute for Clinical Chemistry, University Hospital Zurich, Switzerland; 2Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Switzerland; 3Medical Intensive Care Unit, University Hospital Zurich, Switzerland
0945-1000	O4124 The effect of decontamination procedures on the pharmacokinetics of venlafaxine in overdose Venkata V Pavan Kumar1, Susanna Oscarsson2, Lena E Friberg2, Geoffrey K Isbister3, L Peter Hackett4, Stephen B Duffull . 1School of Pharmacy, University of Otago, Dunedin, New Zealand, 2Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden, 3Department of Clinical Toxicology, Calvary Mater Newcastle Hospital, Newcastle, 4Clinical Pharmacology and Toxicology, PathWest Laboratory Medicine WA, Perth, Australia.
Room 3
0900-0915	O4131 Quantification of haloperidol, olanzapine, risperidone and clonazepam in plasma using UPLC-MS/MS Katrien Lanckmans, Jens Van Den Berghe, Viviane Maes. Laboratory of Clinical Chemistry and Radio-Immunology, UZBrussel, Laarbeeklaan 101, B-1090 Brussels, Belgium
0915-0930	O4132 Quantitative analysis of anthracyclines in biological fluids: is salivary drug monitoring an option to assess toxicity? Kristof E. Maudens and Willy E. Lambert. Laboratory of Toxicology, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium
0930-0945	O4133 Chronic alcohol consumption worsens the outcome of leukemia Fried virus infection. M.G. Neuman, Department of Pharmacology University of Toronto, Toronto, ON, Canada; In Vitro Drug Safety and Biotechnology, MaRS, Toronto, ON, Canada
0945-1000	O4134 MIDAZOLAM MEASUREMENTS BY HPLC AND IMMUNOASSAY IN BRAIN-DEATH DIAGNOSTICS Rainer W. Schmid, Stefan Unterweger, Josef Ebner. Dept. Medical and Chemical Lab Diagnostics, Medical University of Vienna, Vienna, Austria.
Oral Session 4.2, 1030-1130
Room 1
1030-1045	O4211 Urine Drug Excretion Reference Intervals in Pain Patients. Amadeo Pesce, Sergey Latyshev, Perla Almazan, Charles Mikel, Robert West, Bridgit Crews. Millenium Laboratories of California, San Diego, CA 92127 USA
1045-1100	O4212 Quantification of metformin by LC-MS/MS in serum samples of patients with severe lactate acidosis Keller Tanja, Gutteck-Amsler Ursula, Rentsch Katharina M. Institute for Clinical Chemistry, University Hospital Zurich, Switzerland
1100-1115	O4213 Real time busulfan plasma concentration determination with an automated immunoassay. S. J. Salamone1, C. N. Benfield1, J. B. Courtney1, R. L. Harney1, D. R. Kozo1, Y.Li1, G.D. Lundell1 1Saladax Biomedical Inc., Bethlehem, PA, USA
1115-1130	O4214 Hypersensitivity syndrome reactions to ibuprofen Manuela Neuman1, Neil H. Shear2, Manuel Gomez3, Joel S. Fish3, Roberto Cartotto3, Stephen Holzapfel4, Lawrence Cohen5. 1In Vitro Drug Safety and Biotechnology, Pharmacology, 2Dermatology and Drug Safety Clinic, 3Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Department of Medicine, 4Family Medicine, Women's College Health Science Centre and Department of Medicine, 5Gastroenterology and Medicine, Sunnybrook Health Sciences Centre, Department of Medicine, 1,3,4,5University of Toronto, Toronto, Canada
Room 2
1030-1045	O4221 Development Of A Drugs Screening Method In Biological Matrices Using An Hybrid LC-MS/MS System V.Viette1,2,5, M. Fathi1,5, D.Hochstrasser1,4,5, R. Mylonas3, Y. Mauron3, S. Rudaz4,5, J.-L. Veuthey4,5. 1Department of genetic medicine and laboratory, Service of laboratory medicine, Toxicology laboratory, Geneva University Hospital, 2ADMed Fondation, La Chaux-de-Fonds, 3Geneva Bioinformatics (GeneBio) SA, 4School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 5 Swiss Center of Applied Human Toxicology, CMU, Geneva, Switzerland
1045-1100	O4222 Hyphenated Mass Spectrometry in Metabolism Studies – Which Technique Should be Used Today? Dirk K. Wissenbach, Markus R. Meyer, Anika A. Philipp, Daniela Remane, Andrea E. Schwaninger, and Hans H. Maurer. Department of Experimental and Clinical Toxicology, Saarland University, D-66421 Homburg (Saar), Germany.
1100-1115	O4223 Population Pharmacokinetic Study of Methotrexate in Children With Acute Lymphoblastic Leukemia Chao Zhang[1,2], Long Yang[3], Hui Wu[3], Jun Zhang[3], Xiaoyan Ke[4], Suodi Zhai[1,2]* 1Department of pharmacy of Peking University third hospital, Beijing, China, and 2The therapeutic drug monitoring and clinical toxicology center of Peking University, Beijing, China and 3Department of Pharmacy of the First Affiliated Hospital of Kunming Medical School, Kunming, China and 4Department of Hematology of Peking University Third Hospital, Beijing, China
1115-1130	O4224 Steady-state Stereospecific Pharmacokinetics (PK) of Bupropion SR in Juvenile Patients. J. M. Perel1, G. R. Rudolph1, W. B. Daviss2. University Of Pittsburgh, Pittsburgh, PA1 and University of Texas HSC, San Antonio, TX2
THURSDAY OCTOBER 8, 2009
Oral Session 5.2, 1030-1130
Room 1
1030-1045	O5211 Therapeutic Drug Monitoring of Stiripentol in combination with Clobazam and Valproic acid in a young girl with SMEI Edelbroek PM, Segers JP, Augustijn PB. SEIN, Epilepsy Institute in the Netherlands , Heemstede , The Netherlands
1045-1100	O5212 Population pharmacokinetic of intravenous and oral voriconazole in children Nastya Kassir1, Yves Théorêt2,3, Catherine Litalien5, Bruce Tapiero4, Michel Duval4, Line Labbé1, Philippe Ovetchkine4,5. Faculty of Pharmacy1, Department of Pharmacology2, Université de Montréal, Montreal, Canada. Departments of Biochemistry3, Pediatrics4, Clinical Pharmacology Unit5, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Canada.
1100-1115	O5213 Therapeutic drug monitoring of everolimus in heart transplant patients depending on cyclosporine or tacrolimus co-administration Pawel K. Kunicki1, Piotr Przybylowski2, Malgorzata Sobieszczanska-Malek3 1Clinical Pharmacology Unit and 3Department of Heart Failure and Transplantology, Institute of Cardiology, Warsaw, Poland; 2Department of Cardiovascular Surgery and Transplantology, Institute of Cardiology, Jagiellonian University, Cracow, Poland
1115-1130	O5214 Pharmacokinetics profile of Valganciclovir in pediatric transplant recipients Elise Launay¹, Yves Théôret², Catherine Litalien 2, 3, Michel Duval4, Fernando Alvarez5, Anne-Laure Lapeyraque6, Diane Larocque7, Bruce Tapiéro¹, Valérie Lamarre¹ and Philippe Ovetchkine1. 1 Pediatric Infectious Disease Division, Dept of Pediatrics, 2Clinical Pharmacology Unit, Dept of Clinical Biochem., 3Intensive Care Unit, Dept of Pediatrics, 4Onco-Hematology Division, Dept of Pediatrics ,5Hepato-Gastro-Enterolgy Division, Dept of Pediatrics, 6Nephrology Division, Dept of Pediatrics, 7Dept of Pharmacy, CHU Sainte-Justine – Université de Montréal, Montréal
Room 2
1030-1045	O5221 Tacrolimus blood level profile after lung transplantation in a patient with cystic fibrosis (CF), who acquired aspergilus infection: A case study. Hundie Tesfaye1, Richard Prusa1 Richard Lischke2, Jan Simonek2 Blanka Jedlickova1 1Department of Clinical Biochemistry and Pathobiochemistry, Division of Clinical Pharmacology, Faculty Hospital, Motol, 2nd Faculty of Medicine , 2III.Department of Surgery, 1st Medical School, Charles University, Czech Republic
1045-1100	O5222 Is Calcineurin Activity Useful as a Biomarker to Optimize Cyclosporine A Therapy in Renal Transplant Recipients? R.R. Press1,2^, H.H. van Rossum3^, B.A. Ploeger4,5, J. den Hartigh1, J. van Pelt3, H.-J. Guchelaar1, J.W. de Fijter2 and M. Danhof4,5. Departments of 1Clinical Pharmacy and Toxicology, 2Nephrology, 3Clinical Chemistry, Leiden University Medical Center, 4Leiden Amsterdam Center for Drug Research (LACDR), 5Leiden Experts on Advanced Pharmacokinetics and Pharmacodynamics (LAP&P Consultants BV), The Netherlands
1100-1115	O5223 Population Pharmacokinetics of Carbamazepine and Its Metabolite in Chinese Children with Epilepsy Li Wang, Ying Liu, Pediatric Neurology, Peking University First Hospital, Beijing China
1115-1130	O5224 Limited Sample Based AUC Monitoring of Busulfan in Paediatric Patients. Hundie Tesfaye, Eva Klapkova, Richard Prusa. Department of Clinical Biochemistry and Pathobiochemistry, Division of Clinical Pharmacology, Faculty Hospital Motol, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic
Room 3
1030-1045	O5231 Whole Blood Total Cannabinoids during Multiple Daily Oral THC Dosing David M. Schwope1, Eugene W. Schwilke1, Erin L. Karschner1, David A. Gorelick2, Robert S. Goodwin1, Ross H. Lowe1, Deanna L. Kelly3 and Marilyn A. Huestis1. 1Chemistry and Drug Metabolism and 2Office of the Scientific Director, IRP, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA 3Maryland Psychiatric Research Center, University of Maryland, Catonsville, MD, USA
1045-1100	O5232 HIGH INTRA-INDIVIDUAL VARIABILITY IN CLEARANCE OF TACROLIMUS IS A RISK FACTOR FOR POOR LONG-TERM OUTCOME AFTER KIDNEY TRANSPLANTATION L.C.P. Borra1, J.I. Roodnat2, J.A. Kal2, R.A.A. Mathot1, W. Weimar2, T van Gelder1 2. 1Dept. of Hospital Pharmacy, 2Dept. of Internal Medicine Erasmus MC, Post Box 2040, 3000CA, Rotterdam, the Netherlands.
1100-1115	O5233 Promotion of applied pharmacokinetics through a national quality control program : a pilot experience P Wallemacq1, I Delattre1, N Devleeschouwer2, C Van Campenhout2, JC Libeer2. 1 Université catholique de Louvain, Clinical Chemistry Dept, 2Public Health Institute Louis Pasteur, Brussels
1115-1130	O5234 Population Pharmacokinetics of Cyclosporin in Patients Undergoing Allogeneic Stem Cell Transplantation A.J. Wilhelm1, P. de Graaf1, A.I. Veldkamp1, E.L. Swart1, P.C. Huijgens2. 1Departments of Clinical Pharmacology, 2Hematology, VU University medical center , PO Box 7057, 1007 MB, Amsterdam, The Netherlands.

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