POSTER PRESENTATIONS
Information for Presenters
• Prepare your poster to fit within a display board size of: 4 feet high x 8 feet wide
• Each poster will be on display for one day of the Congress, and each day there will be a dedicated poster viewing time from 1130-1230
• Mount your poster by 0900 the morning of your presentation; Take down your poster at 1700 on the afternoon of your presentation
• Posters will be on display in the exhibit hall. Dedicated poster viewing time will be held between 1130-1230, and we ask that you are available at your poster during this period to present your poster
Update: September 14, 2009
Late Abstracts
The Congress Organizers have advised that new abstracts with late-breaking information of particular interest can be submitted to the Congress for poster presentation. Contact us for more information.
P201
UKNEQAS Pilot Surveys for Drugs of Abuse in Oral Fluid
Matthew Gist1, Kathleen Barnett1, John F. Wilson2. 1Cardiff Bioanalytical Services Ltd., 16 Mount Stuart Square, Cardiff CF10 5DP; 2Department of Pharmacology, Radiology & Oncology, Wales College of Medicine. Cardiff University, Cardiff CF14 4XN, UK.
P202
Hair analysis to demonstrate administration to a woman of sildenafil in a case of drug-facilitated sexual assault
Marion Villain, Vincent Cirimele, Pascal Kintz. Laboratoire ChemTox, Illkirch, France.
The drug sildenafil (Viagra, Pfizer) and more recently tadalafil (Cialis, Lilly-Icos) and vardenafil (Levitra, Bayer) have drawn public attention to aphrodisiacs. The search for such substances dates back millennia.
P203
Drug-facilitated sexual assault – The observations of a UK based laboratory. Jennifer Button, Susannah Davies and David W Holt. Analytical Unit, St Georges - University of London, UK
P204
Dead Drunk? - Ethyl Glucuronide and Ethyl Sulphate as Indicators of Post-Mortem Fermentation
Jennifer Button1, Russell Watts2, Michelle Wood2 and David W Holt1 Analytical Unit1, St Georges - University of London, UK and Waters Corporation2, MS Technologies Centre, Manchester, UK
P205
SmileMS: A new Mass Spectrometry Identification Platform for Acute Clinical Toxicology
Roman Mylonas1; Yann Mauron1; Alexandre Masselot2; Pierre-Alain Binz1,2,3; Marc Fathi3,4; Veronique Viette3,5; Denis F Hochstrasser3,4,5; Frederique Lisacek1
1Swiss Institute of Bioinformatics, Geneva, Switzerland; 2Geneva Bioinformatics (GeneBio) S.A., Geneva , Switzerland 3Swiss Center for Applied Human Toxicology, Geneva, Switzerland; 4Geneva University Hospitals, Geneva, Switzerland; 5ADMed Fundation, La Chaux-de-Fonds, Switzerland;
P206
Effect of oral activated charcoal in the treatment of poisoning: A systematic review
Wei Liu, Quanzhi Li, Fang Liu, Jingli Duan. Department of Pharmacy, Peking University Third Hospital, Beijing, China, Jingli Duan, associate professor, Dept. of Pharmacy, Peking University Third Hospital, Beijing, China.
P207
High-throughput quantification of cotinine in urine, serum and meconium by UPLC-MS-MS with automated SPE
Éric Langlois, David Bisson, Michel Lefebvre, Yves Simard, Centre de Toxicologie du Québec, Institut National de Santé Publique du Québec, Canada
P208
Toxicology POCT Devices….Then and Now
Donald LeGatt, Yvette Boisvert, Penny Colbourne, DynaLIFEDx, Edmonton, Canada.
P209
Statistical optimization of a heaspace SPME-GC method for the determination of ethanol and related volatile compounds in blood and oral fluid.
Rafael Linden, Lilian Feltraco and Marina V. Antunes. Instituto de Ciências da Saúde, Centro Universitário Feevale, Novo Hamburgo-RS, Brazil
P210
Determination of Nicotine and Metabolites in Urine, Serum, Plasma and Meconium by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Stephanie J. Marin1, Bingfang Yue1, Beth Cottam2, Alan L. Rockwood3,4, Gwendolyn A. McMillin3,4, 1ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, 2ARUP Laboratories, Inc., Salt Lake City, UT, 3Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT
P211
LCMSMS Extends the Range of Drug Analysis in Pain Patients
Charles Mikel, Amadeo Pesce, Sergey Latyshev, Perla Almazan, Robert West, Bridgit Crews. Millenium Laboratories of California, San Diego, CA,USA
P212
Evaluation of drugs of abuse assays in urine on the Siemens Dimension Vista analytical system.
T. Plecko, E. Wieland, M. Shipkova. Central Institute for Clinical Chemistry and Laboratory Medicine Klinikum Stuttgart, Germany.
P213
Identification of drug metabolites through routine application of a LC-MS/MS General Unknown Screening procedure in forensic toxicology.
François-Ludovic Sauvage1,2,3, Nicolas Picard1,2,3, Franck Saint-Marcoux1,2,3, Jean-Michel Gaulier2, Gérard Lachâtre2,3, Pierre Marquet1,2,3. 1Inserm UMR-S850, Limoges France; 2CHU Limoges, Department of Pharmacology-Toxicology, Limoges, France; 3Univ Limoges, France.
P214
Cyclophosphamide contamination observed on the external surfaces of drug vials and the efficacy of cleaning on vial contamination
Touzin K1, Bussières JF1, Langlois E2, Lefebvre M2, Gallant C3. 1Pharmacy Practice Research Unit, Pharmacy Department, CHU Sainte-Justine, Montreal, Quebec, Canada , 2Clinical Laboratory unit (Human Toxicology Department) Institut national de santé publique du Québec, Canada, 3Association pour la santé et la sécurité au travail – secteur affaires sociales (ASSTSAS), Montréal, Québec, Canada
P215
Quantitative Analysis of Multiple Psychotherapeutic Drugs in Human Serum using UPLC®/MS/MS
R. Watts1, EP. Spencer2 and M.Wood1. 1Waters Corp. MS Technol. Centre, Manchester, UK; 2Guy’s and St Thomas’ NHS Foundation Trust, Med. Toxicology Unit, London, UK
P216
Comparison of Seven Population Methods for Predicting Vancomycin Trough Concentration.
Al-Lanqawi Y1, Capps P2, Abudlmalek K3, Thusu A4, Shihab A1. 1Drug and Poison Information Center, Pharmacy Department, Al-Amiri Hospital, Kuwait, 3Departments of Intensive Care and 4Medicine, Al-Amiri Hospital, Kuwait, 2Department of Pharmacy Practice, Faculty of Pharmacy, Kuwait University.
P217
Systemic measurement of TDS®-Diazepam, compared with Rectal Diazepam, a pharmacokinetic study in Healthy Adult Subjects
F Al-Otaibi1, A Johnston1, AT Tucker1, 2, T Lee3, R Langford4, S Ratcliffe4, K. Kirby5, C. Alam6. 1Clinical Pharmacology, 6 Experimental Pathology, William Harvey Research Institute, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ. U.K. 2 Clinical Microvascular Unit, and 4 Anaesthetics Department, St. Bartholomew’s Hospital, West Smithfield, London. EC1A 7BE. U.K. 3Analytical Unit St George's University of London. Cranmer Terrace London SW17 0RE UK. 5The Langford Research Institute, 521 Northlake Blvd, North Palm Beach FL 33408. USA
P218
Development of high performance liquid chromatograph method for analysis of tetracaine for a tape stripping pharmacokinetic study: a comparison with capillary zone electrophoresis (CE)
F. Al-Otaibi1, E. A. Ghazaly1, A. T. Tucker1, A. Johnston1, D. Perrett3
1Clinical Pharmacology and 3 BioAnalysis, William Harvey Research Institute, Barts & The London, School of Medicine and Dentistry, London UK.
P219
Rapid analysis of tetracaine for a tape stripping pharmacokinetic study using short-end capillary electrophoresis.
F. Al-Otaibi1, A. T. Tucker1, 2, A. Johnston1, D. Perrett3
1Clinical Pharmacology, William Harvey Research Institute, Barts & The London, School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK. 2 Clinical Vascular & Microvascular Unit, Dept of Clinical Physics, St Bartholomew’s Hospital, London EC1A 7BE, UK. 3 BioAnalysis, William Harvey Research Institute, Barts & The London, School of Medicine and Dentistry, Charterhouse Square, London, UK.
P220
Title: Comparison of trough concentrations of tacrolimus in solid organ transplant outpatients converted from twice a day formulation to once-daily formulation Yolanda Armendáriz, PharmD1. Helena Colom, PhD2. Maria Somolinos, M.D1 Pilar Fernandez, Bsc D1 Leonor Pou, PhD1.1 Clinical Biochemistry Service, Hospital Universitari Vall d’Hebron,Barcelona. 2 Pharmacokinetics and Biopharmacy Dept. Pharmacy Faculty. Universidad de Barcelona, Spain
P221
Pharmacokinetics of mycophenolate acid in pediatric liver transplant recipients to optimize MMF dose
C. Barau1, D. Habes2, D. Debray2, AM Taburet1, V. Furlan1. 1Clinical pharmacy and 2department of pediatric hepatology AP-HP, CHU de Bicêtre, Paris, France..
P222
Evidence for hematocrit influence on Tacrolimus apparent clearance and application for TDM in renal transplant recipients
Benkali K1, Prémaud A1, Picard N1, Rérolle JP2, Hoizey G3, Toupance O4, Villemain F5, Turcant A6, Le Meur Y1,7, Rousseau A1, Marquet P1.
INSERM UMR-S8501, University of Limoges, France; Departments of nephrology of Limoges2, Brest7, Reims4 and Angers5 university hospitals, France; Department of pharmacology, Reims3 and Angers6 university hospitals, France.
P223
Population Pharmacokinetics of Steady-State Carbamazepine in Egyptian Epilepsy Patients. Ehab S.ELDesoky1*, Sreedharan N. Sabarinath2, Mostafa M Hamdi*, Michael Bewernitz2, Hartmut Derendorf2. 1Pharmacology Dept, College of Pharmacy, Qassim University, Saudi Arabia, 2Dept. of Pharmaceutics, College of Pharmacy University of Florida Gainesville, *Pharmacology Dept, Faculty of Medicine, Assiut University, Egypt.
P224
ESTIMATION OF MYCOPHENOLIC ACID AUC BY MEANS OF POPULATION PHARMACOKINETICS AND MULTI-LINEAR REGRESSION
Michal J. Figurski, Leslie M. Shaw. University of Pennsylvania, Philadelphia, USA.
P225
Are mycophenolic acid glucuronides pharmacologically active on Inosine MonoPhophate DeHydrogenase type II (IMPDH II)?
Gensburger O, Picard N, Marquet P. INSERM UMR-S 850, France; Univ Limoges, France; CHU Limoges, France.
P226
Pharmacokinetics of Vancomycin in Neonates Admitted to the Neonatology Unit at Jordan University Hospital
Yacoub Irshaid1, Iman Badran2, and Abdulqader Shamayleh2. Departments of 1Pharmacology and 2Pediatrics, Faculty of Medicine, University of Jordan, Amman 11942, Jordan.
P227
Therapeutic Monitoring of Valproic Acid During Delivery, in The Neonatal Period, and During Lactation
Kacirova Ivana, Grundmann Milan, Koristkova Blanka, Brozmanova Hana
Department of Clinical Pharmacology, University Hospital and Faculty of Health Studies, Ostrava, Czech Republic.
P228
Platinum concentrations in plasma and vitreous humour after periocular and transcorneal administration of carboplatin
1Kukacka J., 1Tesfay H., 2Pochop P., 2Darsova D., 1Klapkova E., 3Uhlik J., 1Prusa R.
1Department of Clinical Biochemistry and Pathobiochemistry, 2Department of Ophthalmology for Children and Adults, Charles University 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic, 3Department of Histology, Charles University 2nd Faculty of Medicine, Prague, Czech Republic
P229
Unexpected high variability of extemporaneously prepared oral suspensions of tacrolimus.
Lapeyraque AL1,2, Beauchamp D3, Forest JM3, Théorêt Y1,4, Raboisson, MJ1,2, Martin, S2 and Litalien C1,2. Unité de Pharmacologie Clinique1, Département de Pédiatrie2, Département de Pharmacie3 et Département de Biochimie Clinique4, Centre Hospitalier Universitaire Ste-Justine/Université de Montréal, Montréal (Québec), Canada H3T 1C5
P230
Differences in pharmacokinetic profiles and dosing with different mycophenolate formulations in renal transplant patients
Mathew BS1, Fleming DH1, John GT2. 1Clinical Pharmacology Unit, 2Department of Nephrology, Christian Medical College, Vellore, India
P231
Population Pharmacokinetics and Dose Adjustment Strategy of Cyclosporine in steroid-resistant nephrotic patients
Satoru Ogahara1, Takao Saito1, Masayo Ueno2 , Hideki Shuto3, Atsushi Yamauchi3, Yasufumi Kataoka3, Tomohiro Sasaki4, Ichiro Ieiri4, Shun Higuchi4. 1Division of Nephrology and Rheumatology,Dept. of Internal Medicine,Fukuoka University School of Medicine, 2Dept. of Pharmacy, Fukuoka University Hospital, 3Department of Pharmaceutical Care and Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 4Dept. of Clinical pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
P232
PHENYTOIN AND HEMODIALYSIS-TWO CASE REPORTS
Outeda Macías M, Salvador Garrido P, Martín Herranz I.
Pharmacy Department. A Coruña University Hospital. A Coruña. Spain.
P233
Limited Sampling Strategy for The Estimation of Saquinavir Area Under the Plasma Concentration-Time Curve in Adult Patients Undergoing Antiretroviral Therapy.
T. Pawinski 1, B. Gralak 1, P. Pulik 2, A. Horban 2. 1 Department of Drug Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland. 2 Centre of Diagnostic and Therapy of AIDS, Hospital of Infectious Diseases, Warsaw, Poland.
P234
VALPROIC ACID AND HEMODIALYSIS
Salvador Garrido P, Outeda Macías M, Martín Herranz I. Pharmacy Department. A Coruña University Hospital. A Coruña. Spain.
P235
IMPORTANT REDUCTION IN CYCLOSPORINE LEVELS WITH RIFAMPICIN DESPITE P450 INHIBITORS: A CASE REPORT
Salvador Garrido P, Outeda Macías M, Rabuñal Alvárez MT, España Valiño L, Martín Herranz I. Pharmacy Dept., A Coruña University Hospital. A Coruña. Spain.
P236
EFFECT OF DILTIAZEM ON THE PHARMACOKINETICS OF EVEROLIMUS – TACROLMUS COMBINATION IN RENAL TRANSPLANT PATIENTS
S. Solari1, J. Domínguez2, C. Aravena2, R. González2, F. Jara1, S. Muñoz2, L. Alfaro2, L. Ponce2, AM. Guzman1. 1Clinical Laboratory Department, School of Medicine, Pontificia Universidad Católica de Chile; 2Transplant Unit, Urology and Nephrology Service, Hospital Sótero del Río. Santiago, Chile.
P237
Pharmacokinetics-based optimal dose-exploration of mycophenolate mofetil in allogeneic hematopoietic stem cell transplantation.
Motohiro Yamamori, Atsuo Okamura, Shinichiro Nishikawa, Midori Hirai, Toshimitsu Matsui, Department of Hospital Pharmacy, Kobe University Hospital, Kobe, Japan, Hematology/Oncology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
P301
NOVEL DERIVATIVE ULTRAVIOLETSPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF DIHYDROARTEMISININ
Chinedum P. Babalola, Isaac O. Falana and Yetunde Kolade. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan, Nigeria
P302
An on-line extraction LC-MS method for screening and quantification of multiple therapeutic drugs in human urine.
Barbora Brazdova, Marta Kozak, Thermo Fisher Scientific, San Jose, CA
P303
Quantitative method implementing fast polarity switching quadrupole mass spectrometry for analysis of ten anti-epileptic drugs in plasma samples.
Barbora Brazdova, Marta Kozak, Thermo Fischer Scientific, San Jose, CA
P304
QMS® LEVETIRACETAM ASSAY ON THE HITACHI® 917 SYSTEM
Gary Gunther1, Aimee Rinas1, Aniruddha Patwardhan1, Dave Berry2 and Lili Arabshahi1; 1Thermo Fisher Scientific, Indianapolis, IN, USA; 2Medical Toxicology Unit, St Thomas' Hospital, London, UK.
P305
A Clinical Assay for the Measurement of Milrinone in Plasma by HPLC Mass Spectrometry.
Chihoho B 1, Sage A. B 2, Smolenski R.T.3, Rose M.L. 1,3, Leaver N.V. 1 . 1Royal Brompton & Harefield NHS Trust, Harefield, Middlesex, UK. 2 Agilent Technologies, Wokingham, Berkshire,UK. 3 National Heart & Lung Institute, Imperial College, London,UK.
P306
Performance evaluation of an Affinity Column Mediated Immunometric Assay for Tacrolimus
Hee-Jung Chung, M.D. 1, Jae-Woo Chung, M.D. 1, Dongheui An, M.D. 1, Junghan Song, M.D2. Hae-Il Park, M.D. 3, Woochang Lee, M.D. 1, Sail Chun, M.D. 1, and Won-Ki Min, M.D1
1Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 2Seoul National University College of Medicine, Seoul; 3The Catholic University of Korea, College of Medicine, Seoul, SOUTH KOREA.
P307
Suitability of Becton Dickinson Vacutainer? Rapid Serum Tube (RST) for Collecting and Storing Blood Samples for Anticonvulsant and Antibiotic Therapeutic Drug Monitoring
Y. Chen1, W. Walsh2, Y. Wang3, P.Y. Wong1,3, D. Colantonio1,2. 1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; 2Division of Clinical Biochemistry, Hospital for Sick Children, Toronto, Ontario, Canada; 3University Health Network, Toronto, Ontario, Canada
P308
Plasma Free Metanephrines Quantitation Using Online Sample Extraction Coupled with Tandem Mass Spectrometry
Yang Shi, Catherine Lafontaine, Chris Esposito, François Espourteille. Thermo Fisher Scientific, Franklin, MA 02038
P309
Influence of Co-administered Antiepileptic Drugs on Serum Phenytoin Concentrations in Epileptic Patients: Quantitative Analysis Based on a Suitable Parameter
N. Fukuoka, K. Yamaguchi, T. Tatsumichi, M. Watanabe, N. Shinohara, H. Tanaka, S. Kosaka, H. Houchi. Department of Pharmacy, Kagawa University Hospital, Japan
P310
Plasma selenium ICP-MS analytical validation
Jean-Pierre Goullé1,2, Loïc Mahieu1, Elodie Saussereau1, Michel Guerbet2 and Christian Lacroix1 1Laboratoire de toxicologie, Groupe Hospitalier, Le Havre, France; 2Facuté de médecine et de pharmacie, Rouen, France
P311
Quantification of the HIV-integrase inhibitor Raltegravir in human plasma by HPLC with fluorescence detection
RM López1, JL Blanco2, M Martín1, J Mallolas2, D Guillén1, JM Gatell2, M Brunet1.
1Pharmacology and Toxicology Laboratory (CDB). 2Infectious Diseases Department. Hospital Clínic. IDIBAPS. Barcelona. Spain
P312
Evaluation of an LC/MS/MS reagent kit for the determination of Everolimus and Cyclosporin A in human whole blood using isotopically labelled internal standards.
Gareth W Hammond, Donald P Cooper, Michael Morris and Leonie D Harter
Waters Corporation, Atlas Park, Simonsway, Manchester, M22 5PP, UK.
P313
Simultaneous quantification of mycophenolic acid and leflunomide metabolite A77 1726 in human serum by an isocratic methanolic HPLC-UV method with a throughput of 24 injections per hour
Pierre-Olivier Hétu and Bernard Vinet. Pharmacology and Toxicology, Biochemistry department, CHUM – Hôpital Notre-Dame, 1560 Sherbrooke Est, Montréal, Québec, Canada, H2L 4M1.
P314
Assessment of the new tacrolimus CMIA assay in heart, kidney and liver transplantation
C. Bazin1, C. Barau2, A. Guinedor3, C. Gozalo4, H. Marty4, V. Furlan2, L. Massias3, A. Hulin. 1Laboratory of Pharmacology, AP-HP, 1CHU H. Mondor, Université Paris XII Créteil, 2CHU Bicêtre, Université Paris XI, 3GH Bichat-Claude Bernard, Université Paris VII 4CHU Reims, Université Reims (France)
P315
ARK? Homogeneous Enzyme Immunoassays for the Newer Antiepileptic Drugs
K.C. Kasper, B. Moon, J. Nguyen, J. Valencia, K. Chung, A. Orozco, P. Nguyen and J. Valdez - ARK Diagnostics, Inc., Sunnyvale, CA, USA 94089
P316
A rapid, easy-to-use, sensitive, and simultaneous measurement method for CPT-11 and its metabolites using HPLC.
Eiji Kayano, Takaaki Kadobayashi, Ryuji Kato, Yoshio Ijiri, Kazuhiko Tanaka. Laboratory of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences
P317
New simple method for determination of intraconazole and hydroxyitraconazole in human serum
Klapkova E., Kukacka J., Prusa R. Department of Clinical Biochemistry and Pathobiochemistry, Charles University 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
P318
HPLC–ESI- TANDEM MASS SPECTROMETRY DETERMINATION OF
THE CYTOSTATIC AGENT 5-FLUOROURACIL IN HUMAN PLASMA.
M. Korecka, M. Milone, N. Riccio, L.M. Shaw. University of Pennsylvania Medical Center, Philadelphia, USA.
P319
LC-MS/MS method for a high throughput quantitative analysis of immunosuppressant drugs in whole blood
M.Kozak,R.Ruzicka, V.Bodepudi, R.Loor, J.Zonderman. Thermo Fisher Scientific, CA
P320
Determination of valproic acid in serum by high performance liquid chromatography with diode array detection, after derivatization with phenacyl bromide.
Rafael Linden1, Viviane Nagel1, Marina V. Antunes1, Daniele Hermes2 and Helenice O. Werlang2. 1Instituto de Ciências da Saúde, Centro Universitário Feevale, Novo Hamburgo-RS, 2Weinmann Medicina Laboratorial, Porto Alegre-RS, Brazil
P321
EVALUATION OF THE ABBOTT ARCHITECT CYCLOSPORINE ASSAY
G.T. Maine1, D.M. Levine2, S.M. Amann2, T.S. Parker2, J.S. Chang3, T. Lorey3 and C. Hoke3. 1Abbott Diagnostics, Abbott Park, IL USA, 2The Rogosin Institute, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY USA, 3Kaiser Permanente Medical Group, Richmond, CA USA.
P322
A New High-Performance Liquid Chromatography Method for Determination of (R)-Warfarin and (S)-Warfarin using Chiral Separation on Glycopeptide Phase
J. Malakova1, P. Pavek2, I. Jokesova1, P. Zivny1, V. Palicka1. 1Institute of Clinical Biochemistry and Diagnostics, Faculty of Medicine and University Hospital Hradec Králové, Charles University in Prague, Czech Republic, 2 Department of Pharmacology and Toxicology, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Czech Republic
P323
LC-MS/MS of atypical antipsychotic drugs in plasma/serum for TDM
Morgan PE, Fisher DS, Vipond LJ, Flanagan RJ. Toxicology Unit, Clinical Biochemistry, King’s College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS
P324
LC-MS/MS of quetiapine: elimination of metabolite interferences
Morgan PE, Fisher DS, Flanagan RJ. Toxicology Unit, Clinical Biochemistry, King’s College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS
P325
Simple assay of lamotrigine in serum/plasma using strong cation-exchange HPLC
Morgan PE, Fisher DS, Evers R, Flanagan RJ. Toxicology Unit, Clinical Biochemistry, King’s College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS
P326
The Assay of Thymine and Dihydrothymine using HPLC-MS/MS in Human Plasma, Saliva and Urine.
Rani George a,b, Bruce Charles b, John Duley b,c, Ross Norris a,d
a Australian Centre for Paediatric Pharmacokinetics, Mater Pharmacy Services, Mater Health Services, South Brisbane 4101, QLD Australia
b School of Pharmacy, The University of Queensland, St Lucia 4072, QLD, Australia. c Mater Pathology Services, Mater Health Services, South Brisbane 4101, QLD, Australia. d School of Pharmacy, Griffith University Gold Coast Campus 97260, QLD, Australia
P327
The Development and Validation of an Assay for Vincristine in Plasma using HPLC-MS/MS.
Karin Van Breda a, Ross Norris a,b, Ross Pinkerton c, Bruce Charles d
a Australian Centre for Paediatric Pharmacokinetics, Mater Pharmacy Services, Mater Health Services, South Brisbane, QLD 4101, Australia. b School of Pharmacy, Griffith University-Gold Coast, QLD 97260, Australia.c Director of Cancer Services, Royal Children’s Hospital, QLD 4029, and Mater Children’s Hospital, South Brisbane, QLD 4101, Australia. d School of Pharmacy, The University of Queensland, QLD 4072, Australia.
P328
A Survey of Therapeutic Drug Monitoring in Australasia.
Ross Norris1, Ray Morris2, Erin Thompson1, John Ray3, Michael Barras4, Graham Jones5, Jenny Martin6. 1 Australian Ctr for Paed Pharmacokinet, Mater Pharmacy Services, South Brisbane, Qld, 4101, 2Dept of Clin Pharmacol, The QE II Hospital, Woodville, SA, 5011, 3Div of Clin Pharmacol & Toxicol, SydPath, St. Vincent’s Hospital, Darlinghurst, Sydney, NSW, 2010, 4School of Pharmacy, University of Queensland, St Lucia Qld. 4072 ,5Dept of Chem Path, SydPath, St Vincent's Hospital, Darlinghurst, NSW, 2010, 6Depts of Chem Path and Internal Medicine, Royal Brisbane and Women's Hospital, Qld 4029.
P329
Validation of an enzymatic measurement of mycophenolate acid on the ABX Pentra 400 analyzer and comparison with an LC-DAD/MS method in samples from children with nephrotic syndrome.
Parant F1, Ranchin B2, Liutkus A2, Mestrallet G2, Pichault V2, Bonnefond F1, Berthelier M-C1, Gagnieu M-C1. 1Laboratoire de pharmacologie, hôpital E. Herriot, 69437 Lyon, 2Service de néphrologie et rhumatologie pédiatriques, hôpital Femme-Mère-Enfant, Bron, France
P330
Evaluation of Mycophenolic Acid stability in plasma and whole blood.
Jason Tracey, Nigel W Brown, J Michael Tredger. IDM Service, Institute of Liver Studies, Kings College Hospital, London. SE5 9RS UK
P331
Mycophenolic Acid Concentration Monitoring for Mycophenolate Mofetil-treated Graft versus Host Disease.
NW Brown1, P Hiwarkar2, BE Shaw2, S Kulkarni2, R Saso2, S Evans2, J Treleaven2, FE Davies2, ME Ethell2, GJ Morgan2, MN Potter2 and JM Tredger1. 1Institute of Liver Studies, King’s College Hospital, London SE5 9RS and 2Haemato-Oncology Unit, The Royal Marsden Hospital, Sutton SM2 5PT. UK.
P332
Does the Infusion of Local Anaesthetic at the Incision Site Provide Adequate Pain Relief Following Abdominal Surgery? An Interim Analysis.
Sumithra Krishnan1,2, Raymond Morris1, Peter Hewett2, Alex Karatassas2, Julie Tonkin3, John Field4. 1Department of Clinical Pharmacology, Queen Elizabeth Hospital, Woodville, SA, Australia, 2Department of Surgery, University of Adelaide, SA, Australia, 3Department of Anaesthesia, Queen Elizabeth Hospital, Woodville, SA, Australia, 4Faculty of Health Sciences, University of Adelaide, SA, Australia
P333
COMPARISON OF TWO DIFFERENT ASSAYS FOR THE DETERMINATION OF WHOLE BLOOD TACROLIMUS
Hayriye Senturk CIFTCI, Tulay Kilicaslan AYNA, Mehmet GURTEKIN Mahmut ÇARIN. Istanbul University , Istanbul Medical Faculty, Medical Biology Department, Capa-Istanbul.
P334
Mycophenolate mofetil improves kidney function but not survival in a COL4A3-deficient mouse model for progressive renal fibrosis
G. Brandhorst1, F. Brehmer1, D. T. Petrova1, O. Gross2, V. W. Armstrong1, M. Oellerich1. 1Department of Clinical Chemistry, University Hospital Goettingen. Department of Nephrology and Rheumatology, University Hospital Goettingen, Germany
P335
Does Capsaicin induce CYP3A2 in rats?
Yugo Kusukawa, Takako Irie, Ryuji Kato, Yoshio Ijiri, Kazuhiko Tanaka. Laboratory of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences
P336
A rapid method for the determination of azithromycin in plasma by UPLC-MSMS.
Sean J. O’Halloran*, Sam Salman+, Kenneth F. Ilett*, *PathWest Laboratory Medicine, Perth, Western Australia, +University of Western Australia, Perth, Western Australia.
| WEDNESDAY OCTOBER 7, 2009 |
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P401
Low-dose metoprolol associated with central nervous system adverse effects
Amir Ahmed1, Patricia van Mierlo1, Paul Jansen2. 1Department of Geriatric Medicine, Rijnstate Hospital, PO Box: 9555, 6800 TA, Arnhem, 2Department of Geriatric Medicine. University Medical Centre Utrecht, The Netherlands
P402
Immunoassays for the Detection of Opiates, Cocaine, Amphetamines, Methamphetamine, and PCP in Oral Fluid on Automated Instrument Platforms
Tim Corbett1, Daniel Hoch1, Catherine Hurt1, Christopher Lawrence1, Larry Mountain1, Shaker Rashid1, Glenda Soriano1, Justin Stall1, Christopher West1, Howard Woods1, Katherine Yoder1, Yuhong Zhao1, Davina Ananias1, Kristen Blum2, Dean Fritch2, Keith Kardos2 and Steven Lee, 1Roche Diagnostics, Indianapolis, IN, USA; 2OraSure Technologies, Inc., Bethlehem, PA, USA
P403
Influence of Therapeutic Drugs on Testing for Drugs of Abuse in Urine
Kathleen Barnett1, John F. Wilson2. 1Cardiff Bioanalytical Services Ltd, 16 Mount Stuart Square, Cardiff CF10 5DP; 2Dept. of Pharmacology, Radiology & Oncology, Wales College of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
P404
MULTICENTER EVALUATION OF ONLINE DAT® AMPHETAMINES II ASSAY ON ROCHE/HITACHI AND COBAS SYSTEMS
Verstraete A1,Vander Heyden F1, van Gessel H1, Haase W2, LeGatt D3, Shalapay C3, Collins J4, Setterstrom R4, Beck C5, Domke I6, Coffing MJ6. Department of Clinical Biology, Ghent University Hospital, Belgium, 2Medilys, Asklepios Klinik Nord, Hamburg, Germany, 3University of Alberta Hospital/Capital Health, Edmonton, Alberta, Canada, 4MEDTOX Laboratories, St. Paul, Minnesota, 5Roche Diagnostics GmbH, Mannheim, Germany, 7Roche Diagnostics Operations Inc., Indianapolis, IN.
P405
Analysis of the Volatile Alkyl Nitrites (“poppers”)
Susannah Davies1, Josanne Salina2, John Ramsey2, David W Holt1. 1Analytical Unit & 2TICTAC Communications Ltd, Division of Cardiac and Vascular Sciences, St George’s, University of London, UK.
P406
Drugs on the Dance Scene – New Kids on the Block
Susannah Davies1, Jennifer Button1, John Ramsey2, David W Holt1. 1Analytical Unit, &
2TICTAC Communications Ltd, Division of Cardiac and Vascular Sciences, St George’s – University of London, UK
P407
Amphetamine versus non-amphetamine psychosis in Saudi patients hospitalized from a psychiatric emergency service for first episode of acute psychosis.
Ashraf MA.EL-Tantawy1*, Ehab S. ELDesoky2+*, Abdulhameed AL-Yahya3+*, Yasser M Raya3+*. 1Buraidah Mental Health Hospital, Ministry of Health, 2Pharmacology Dept, College of Pharmacy, 3Dept of Psychiatry, College of Medicine, +Qassim University, *Kingdom of Saudi Arabia.
P408
Evaluation of the usefulness of an oxycodone immunoassay in combination with a traditional opiate immunoassay for the screening of opiates in urine.
Marie Gingras1, Marie-Hélène Laberge2, Michel Lefebvre2. 1Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Canada and 2Centre de toxicologie du Québec, Institut National de Santé Publique du Québec, Quebec City, Canada
P409
On line sample extraction technique vs traditional sample preparation methods for LC-MS forensic toxicology screening
Guifeng Jiang, Marta Kozak, Subodh Nimkar, James Byrd, Thermo Fisher Scientific , San Jose, CA
P410
DRUGS OF ABUSE AND ANTICONVULSIVANTS: A CASE REPORT
Outeda Macías M, Salvador Garrido P, Martín Herranz I. Pharmacy Department. A Coruña University Hospital. A Coruña. Spain.
P411
MONITORING COTININE IN ORAL FLUID AND URINE.
Rainer W. Schmid 1, Lydia Halwachs 1, Bettina Steyrer 1,2
1Dept. of Medical & Chemical Lab Diagnostics, University Hospital - Medical University of Vienna, Vienna, Austria, 2Greiner Bio-One, Kremsmünster, Austria.
P412
Characterization of Patients with Positive Results to Cocaine and/or Cannabis in the Toxicology Laboratory of the Catholic University of Chile Medical Center
S. Solari, C. Selman, F. Jara, F. Allende, JC. Ríos, M. Lagos, AM Guzmán.
Departamento de Laboratorios Clínicos, Facultad de Medicina, Pontificia Universidad Católica de Chile. Santiago, Chile.
P413
The mechanisms of acyclovir – induced nephrotoxicity in children
Gunness P1,2, MSc., Aleksa, K1, PhD., and Koren G1,2, MD. FRCP(C)
1Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada; 2Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
P414
Effect of pH Gradient on Valproic acid Transport across Trophoblasts Using the High-Throughput Method with Differentiating Human Choriocarcinoma JEG-3 Cells
Kenji Ikeda1, Naoki Utoguchi2, Michiaki Myotoku1 and Yoshihiko Hirotani1
1Laboratory of Clinical Pharmaceutics, Faculty of Pharmacy, Osaka Ohtani University, , Osaka, Japan, 2Department of Biopharmaceutics, School of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
P415
Effect of Mint Drink on Metabolism of Nicotine as Judged by Nicotine to Cotinine Ratio in Urine of Jordanian Smoking Volunteers.
Abdulrahman Ghazi, Abdulazim Salhab and Yacoub Irshaid. Department of Pharmacology, Faculty of Medicine, University of Jordan, Amman 11942, Jordan.
P416
Biomonitoring of Cytotoxic Drugs by Screening with UPLC-DAD-MSMS in a Central Reconstitution Unit
J. F. Wiart1, L. Humbert1, R. Baccouch2, M. Yilmaz2, M. Lhermitte1. 1Laboratoire de Toxicologie & Génopathies, Centre de Biologie Pathologie - CHRU de Lille, and Université Lille Nord de France 59037 Lille France, 2 URCC- Pharmacie centrale CHRU de Lille, 59037 Lille France
P417
Cocaine Trends: Experiences of a UK based Forensic Toxicology Laboratory
Verity Hayward, Sheri Ledbetter, Jennifer Button and David W Holt. Analytical Unit, St. George’s, University of London, UK
P418
Khat: A bundle of fun or a bunch of problems?
Jennifer Button1, John Corkery2 and David W Holt1. Analytical Unit1 and National Programme on Substance Abuse Deaths (np-SAD), International Centre for Drug Policy2, St George’s - University of London, UK
P419
Fatal intoxication with duloxetine: report of four cases
Guillaume Hoizey1, Marc Deveaux1, Marjorie Cheze1, Eric Medrano1, Julie Evans2, Gilbert Pépin1. 1Laboratoire TOXLAB, Paris, France. 2Eurofins Forensic Services, London, UK
P420
Urine Buprenorphine :Compliance Monitoring - A Clinical Evaluation
Kapur, Bhushan. M1 and Patel, Ketan.2. 1Department of Clinical Pathology, Sunnybrook Health Sciences Center; Faculty of Medicine, The University of Toronto; Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children and 2Integrated Circle of Care Inc. London, Ont. Canada
P421
A Novel Point of Care Test for Serum Acetaminophen and Methanol
Bhushan Kapur1,2, Tracy Yang2 and Kevin Tao2. 1Dept of Clinical Pathology, Sunnybrook Health Science Centre, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto Canada and, 2ZBx Corporation, Toronto, Canada.
P422
Incidence of Metformin Associated Lactic Acidosis estimated from metformin serum concentration measurements
I.R.F. van Berlo-van de Laar, C.G. Vermeij and C.J. Doorenbos. Deventer Hospital, Nico Bolkesteinlaan 75, 7416 SE, Deventer, The Netherlands
P423
COMBINED METHADONE/MORPHINE OVERDOSE OF A METHADONE PROGRAM PATIENT ADMITTED TO HOSPITAL
Brent K. Wilde and Mabood Qureshi
P424
Everolimus (RAD) drug drug interaction (DDI) with azoles antifungals (AF) in transplanted patients.
Berge M1, Amrein C2, Lefeuvre S1,3 , Chevalier P2, Guillemain R2, Boussaud V2, Billaud EM1,3. 1Pharmacology, Hôpital Européen Georges Pompidou, Paris, France, 75015, 2Cardiovascular Surgery, Hôpital Européen Georges Pompidou, Paris, France, 3Paris Descartes University
P425
Manganese-induced neurotoxicity in methamphetamine users infected with hepatitis B and C virus
Kukacka J1, Vajtr D1,3, Vitous A2, Klapkova E1, Tulach M2, Bradkova E3, Prusa R1
1Department of Clinical Biochemistry and Pathobiochemistry, Charles University 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
2Department of Infectology, University Hospital Motol, Prague, Czech Republic
3Department of Forensic Medicine and Toxicology, Charles University 1st Faculty of Medicine, Prague, Czech Republic
P426
Serum markers of neural injury in monitoring of oxaliplatin–related neurotoxicity
1Kukacka J, 2Kubackova K, 1Klapkova E, 1Vajtr D, 2Prausova J, 1Prusa R
1Department of Clinical Biochemistry and Pathobiochemistry, Charles University 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
2Radiotherapy-Oncology Department, University Hospital Motol, Prague, Czech Republic
P427
Immunosuppressive therapy and risk of adverse effects in renal transplant recipients, children after bone marrow transplantation and children with primary glomerulonephritis
Magdalena Hurkacz1, Zuzanna Kobialka1 Magdalena Kuriata-Kordek2, Irena Wikiera-Magott3, Krzysztof Kalwak4, Anna Wiela-Hojenska1, Marian Klinger2, Alicja Chybicka4, Danuta Zwolinska3.
1Department of Clinical Pharmacology, 2Department of Nephrology and Transplantation Medicine, 3Department of Paediatric Nephrology, 4Department of Paediatric Bone Marrow Transplantation, Oncology and Haematology, Silesian Piasts University of Medicine in Wroclaw, Poland:
P428
Effects of lipopolysaccharide on P-glycoprotein expressions and activities in the rat liver and kidney.
Asuka Iwamoto, Jun Moriguchi, Takako Irie, Ryuji Kato, Yoshio Ijiri, Kazuhiko Tanaka
Laboratory of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences
P429
Is CCl4-induced liver injury equal to drug-induced liver injury? - The role of TNF-a on the rat model with CCl4 induced liver injury
Ryuji Kato, Maiko Sadamatsu, Daisuke Sasaki, Mina Takano, Yoshio Ijiri, Kazuhiko Tanaka. Laboratory of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences
P430
Fourteen Years’ Experience of National External Quality Assessment Program for Therapeutic Drug Monitoring in Korea
Woonhyung Lee1, Jeong-Ho Kim1, 2, Jin Q Kim2, Oh Hun Kwon1
1Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea, 2Therapeutic Drug Monitoring Committee, The Korean Association of Quality Assurance for Clinical Laboratory, Seoul, Korea
P431
Identification of the UDP-glucuronosyltransferase (UGT) isoforms involved in buprenorphine glucuronidation and evaluation of the inhibitory potential of this drug on UGTs.
Rouguieg K, Sauvage F-L, Comte J-H, Marquet P, Picard N.
Inserm UMR-S850, Limoges France; CHU Limoges, France; Univ Limoges, France.
P432
The interplay between irinotecan and bilirubin is not on the metabolism by UGT1A1 but on the excretion of irinotecan.
Daisuke Sasaki, Saori Tanaka, Takaaki Kadobayashi, Eiji Kayano, Ryuji Kato, Yoshio Ijiri, Kazuhiko Tanaka. Laboratory of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences
P433
Empirical models for dosage optimization of four ß-lactams in critically ill septic patients based on therapeutic drug monitoring of amikacin
IK Delattre1, FT Musuamba1, RK Verbeeck1, T Dugernier2, H Spapen3, PF Laterre4, FS Taccone5, JL Vincent5, F Jacobs6, PE Wallemacq1
1Laboratory of Clinical Biochemistry, Université Catholique de Louvain, Brussels; 2Intensive Care Unit, St-Pierre Hospital, Ottignies; 3Intensive Care Unit, Universitair Ziekenhuis Brussel, Brussels; 4Intensive Care Unit, Cliniques Universitaires St-Luc, Brussels; 5Intensive Care Unit, 6Infectious Diseases Unit, Hôpital Erasme, Brussels; Belgium
P434
Plasma concentration of 5-fluorouracil is predictive of clinical response after definitive chemoradiotherapy for esophageal squamous cell carcinoma in Japanese
Akiko Kuwahara, Kazusaburo Kataoka, Toshiyuki Sakaeda, Motohiro Yamamori and Takao Tamura. School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya 663-8179, Japan; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan; and Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
P435
Effects of calcineurin inhibitors and implication of efflux transporters and CYP3A on the intestinal flux of mTOR inhibitors.
Lamoureux F, Picard N, Sauvage FL and Marquet P. Inserm UMR-S850, Limoges France; CHU Limoges, France; Univ Limoges, France.
P436
Frequency of Genetic Polymorphisms in the Promoter (C-24T), Exon 10 (G1249A) and Exon 28 (C3972T) Regions of ABCC2 in Australian Renal Transplant Recipients and Donors.
BC Sallustio1,3, IS Westley1,5, JK Coller3, MB Ward4, GR Russ2 and RG Morris1,3. 1Dept. of Clin. Pharmacol. & 2Renal Unit, Queen Elizabeth Hospital, Adelaide, Australia; 3Discipline of Pharmacol., University of Adelaide, Adelaide, Australia; 4School of Pharm. & Biomed. Sci., University of South Australia, Adelaide, Australia & 5Dept of Clin. Biochem., Universite Catholique de Louvain, Brussels, Belgium.
P437
Therapeutic Drug Monitoring and Safety Data of Tacrolimus in Pediatric Renal Transplant Recipients: Retrospective and Prospective Evaluations in Jordanian Children.
Sireen Shilbayeh§ and Issa Hazza'‡ §Associate Professor of Clinical Pharmacy, AL-Isra University, Amman, Jordan ‡Pediatric Nephrology Consultant, Royal Medical Services, King Hussain Medical Center, Pediatric Department, Jordan.
P501
International Tacrolimus Proficiency Testing Scheme Data: A Valuable Resource for Therapeutic Drug Monitoring.
Denise A McKeown, Terrence D Lee, Atholl Johnston and David W Holt. Analytical Unit, St George’s, University of London, UK.
P502
QMS® TEICOPLANIN ASSAY ON THE HITACHI® 917 SYSTEM
Richard Snyder, Aniruddha Patwardhan, and Lili Arabshahi. Thermo Fisher Scientific, Indianapolis, IN, USA
P503
Evaluation of carbamazepine, phenytoine, theophylline and phenobarbital assays on the Siemens Dimension Vista analytical system.
T. Plecko, E. Wieland, M. Shipkova. Central Institute for Clinical Chemistry and Laboratory Medicine Klinikum Stuttgart, Germany.
P504
An HPLC assay for the monitoring of the new antiepileptic drug lacosamide in patients with epilepsy.
Neville Ratnaraj, Clare Greenaway, Philip N. Patsalos. Department of Clinical and Experimental Epilepsy, Pharmacology and Therapeutics Unit, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London and Chalfont Centre for Epilepsy, Chalfont St Peter, UK.
P505
A Routine UPLC-LC/MS/MS Assay for the Newer Antidepressants
James C. Ritchie Ph,D., Bailey Glover M.D. , Clayton Ramsey M.T.S., Patricia Scott-Harrell B.S., Clinical Pathology Translational Research Laboratory, Emory University, Atlanta, GA, USA
P506
A Routine UPLC-LC/MS/MS Assay for the Newer Antipsychotics.
James C. Ritchie Ph,D., Bailey Glover M.D. , Clayton Ramsey M.T.S., Patricia Scott-Harrell B.S., Clinical Pathology Translational Research Laboratory, Emory University, Atlanta, GA, USA
P507
A LC-MS/MS method for the simultaneous evaluation of human glucuronidation enzyme activities using an in vitro cocktail approach.
K Rouguieg1,2, N Picard1,2,3, F-L Sauvage1,3, P Marquet1,2,3. 1INSERM UMR-S 850, France; 2Univ. Limoges, France; 3CHU Limoges, France.
P508
Semi-Automated & Automated Sample Preparation for the Immunological Immunesuppressant Monitoring On the Architect Analyzer
Stefanie Schmid, Beatrix Gruber, Rainer W. Schmid, Dept. of Medical & Chemical Labdiagnostics, University Hospital - Medical University of Vienna, Vienna, Austria
P509
EVALUATION OF THE NEW FPIA FOR THE DETERMINATION OF WHOLE-BLOOD EVEROLIMUS CONCENTRATIONS IN KIDNEY TRANSPLANT RECIPIENTS
Hayriye Senturk Ciftci1, Tulay Kilicaslan Ayna1, Mehmet Gurtekin1, Alp Gurkan2, Sevgi Sahin2, Mahmut Carin1. 1 I.U., Istanbul Medicine Faculty, Medical Biology Department Capa-Istanbul, 2 Gazi Osmanpasa Hospital, Organ Transplantation Center, Gazi Osmanpasa-Istanbul
P510
A simple and ultra-rapid method for measurement of 11 antiretroviral drugs by UPLC-DAD. Olivia L Paku and Edgar P Spencer, Medical Toxicology Laboratory, GSTS Pathology, St Thomas’ Hospital, London, UK.
P511
DETERMINATION OF CLARITHROMYCIN AND 14-HYDROXY-CLARITHROMYCIN IN HUMAN PLASMA BY A VALIDATED LC-MS/MS METHOD
Svinarov D., Kasabova L. Central Laboratory of Therapeutic Drug Management and Clinical Pharmacology, Alexander University Hospital, Faculty of Medicine, Medical University, Sofia, Bulgaria
P512
Measurement of Oxypurinol Concentrations in Urine by HPLC-Tandem Mass Spectrometry
Michael E. Franklin1, Jacqueline M.Anderson2, Sophie L. Stocker2, Peter I. Pillans1, Ken M. Williams2 , Richard O. Day2, Paul J. Taylor 1 . 1Deparment of Clinical Pharmacology, Princess Alexandra Hospital, Brisbane, Australia and 2Clinical Pharmacology, St Vincent’s Hospital, and UNSW, Sydney, Australia.
P513
Simultaneous Measurement of Aldosterone and Cortisol in Plasma by HPLC-Tandem Mass Spectrometry: Application to Sports Medicine Studies
Paul J. Taylor1,2, Simon van Rosendal3, Jeff S. Coombes3, Richard Gordon2, Michael Stowasser2 1Department of Clinical Pharmacology and 2The University of Queensland, Endocrine Hypertension Research Centre, Princess Alexandra Hospital, Brisbane, Australia and 3The University of Queensland, School of Human Movement Studies, Brisbane, Australia.
P514
HPLC-MS/MS assay for the determination of Imatinib and its metabolite CGP74588 concentrations in plasma
I Westley1, V Di Fazio2, R Vanbinst2 & P Wallemacq1,2. 1Laboratoire de Biochimie Medicale, Université Catholique de Louvain, Brussels, Belgium, 2 Department of Clinical Chemistry, University Hospital St. Luc, Brussels, Belgium.
P515
Simultaneous quantification of erlotinib, gefitinib and imatinib in human plasma by liquid chromatography tandem mass spectrometry
A. Chahbouni, A.J. Wilhelm , J.C.G. den Burger, R.M. Vos, A. Sinjewel. VU University medical center, Department of Clinical Pharmacology and Pharmacy, Amsterdam, The Netherlands
P516
Analysis of Cyclosporin A in Dried Blood Spots using Liquid Chromatography Tandem Mass Spectrometry.
J.C.G. den Burger, A.J. Wilhelm, R.M. Vos, A. Chahbouni, A. Sinjewel. VU University Medical Center, Laboratory of Clinical Pharmacology and Pharmacy, Amsterdam, Netherlands.
P517
Eplerenone and digoxin concentrations measured by FPIA, MEIA and ACMIA.
Tomoyuki Yamada1, Kaoru Suzuki1, Ken Iguchi2, Yasutaka Kanada2, Ryuji Kato3, Yoshio Ijiri3, Masami Nishihara1,Sumiko Murakami2, Tetsuya Hayashi4, Kazuhiko Tanaka3, Hiroshi Tamai1. 1Department of Pharmacy, Osaka Medical College Hospital; 2Department of Clinical Laboratory, Osaka Medical College Hospital; 3Laboratory of Clinical Pharmacy and Clinical Pharmacokinetics, Osaka University of Pharmaceutical Sciences; 4Department of Internal Medicine III, Osaka Medical College Hospital
P518
Tacrolimus and protease inhibitors interaction in HIV-infected liver transplant patients
O. Tribut1, C. Camus 2, C. Arvieux2, D. Bentue-Ferrer1.
1Pharmacology, 2Reanimation and infectious diseases, CHU of Pontchaillou, Rennes, France.
P519
Digoxin levels above the reference range in elderly patients
Hundie Tesfaye1, Zoltan Paluch2, Blanka Jelickova1, Jana Skokanova1, Richard Prusa1, Stefan Alusik2, Jana Granatova2, Vera Jedlickova2. 1Department of Clinical Biochemistry and Pathobiochemistry, Division of Clinical Pharmacology, Faculty Hospital, Motol, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic. 2Thomayer's Teaching Hospital, Department of Medicine and Division of Clinical Pharmacology, Prague, Czech Republic
P520
CYP2C19 *2 but not *17 Influence Amitriptyline and Citalopram Serum Concentrations: Intermediate Metabolizer Status may be of Clinical Relevance
Julia Stäker, Heike Schneider, Stefan Leucht*, Konstanze Zöpf, Werner Kissling*, Werner Steimer. Institut für Klinische Chemie und Pathobiochemie, *Psychiatrische Klinik und Polikinik, Klinikum rechts der Isar, TU-München, München, Germany
P521
TaqMan Real-time PCR quantification strategy of CYP2D6 gene copy number for the LightCycler 2.0.
Duc L. Nguyen1, Julia Staeker1, Barbara Laika1, Werner Steimer1. 1Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, Germany
P522
Phenotypization of Cyclosporine A in Stable Renal Transplant Patients
Grundmann M., Duricova J., Marsalkova P., Perinova I., Brozmanova H.
Department of Clinical Pharmacology, University Hospital and Faculty of Health Studies Ostrava University, Czech Republic
P523
Modeled Dissection of Chemoresponse Patient Groups in Colorectal Cancer
Soo-Youn Lee1,2, J. Todd Auman2, Howard L. McLeod2. 1Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 2UNC Institute for Pharmacogenomics and Individualized Therapy, Lineberger Cancer Center and the Schools of Pharmacy and Medicine, University of North Carolina, Chapel Hill, NC, USA
P524
Cytochrome P-450 Isozyme 2C19 Genetic Polymorphisms Are Associated with Plasma Concentrations of Escitalopram
Ming-Hsien Tsai1, Keh-Ming Lin1, Mei-Chun Hsiao2, Winston W. Shen3, Mong-Liang Lu3, Hwa-Sheng Tang4, Chun-Kai Fang5, Chi-Shin Wu6, Shao-Chun Lu7, Shu Chih Liu1, Yu-Li Liu1 1Div. of Mental Health and Substance Abuse Research, National Health Research Institute, 2Dept of Psychiatry, Chang-Gung Hospital and Chang-Gung University School of Medicine,3Dept of Psychiatry, Taipei Medical University-Wan Fang Medical Center, Taipei Medical University, 4Dept of Psychiatry, Taipei City Psychiatric Center, 5Dept of Psychiatry, Mackay Memorial Hospital, 6Dept of Psychiatry, Far Eastern Memorial Hospital, 7Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
P525
Influence of MRP2 and UGT1A9 Polymorphisms in the MPA Pharmacokinetics in renal transplant recipients. Results of the Pharmacogenetic Substudy within the Symphony Study. Lloberas N1, Brunet M2, Torras J1, Cruzado JM1, Oppenheimer F3, Sanchez-Plumed J4, Gentil M5, Ekberg H6, Grinyó JM1.
1Neprhology, Hospital Universitari Bellvitge, Barcelona, 2Toxicology, Centre de Diagnòstic Biomèdic, Barcelona, 3Nephrology, Hospital Clínic i Provincial, Barcelona, 4Nephrology, Hospital de la Fe, Valencia, 5Nephrology, Hospital Virgen del Rocio, Sevilla, Spain, 6Nephrology, Malmoe, Sweden.
P526
Population Pharmacokinetic Study of Methotrexate in Children With Acute Lymphoblastic Leukemia
Chao Zhang[1,2], Long Yang[3], Hui Wu[3], Jun Zhang[3], Xiaoyan Ke[4], Suodi Zhai[1,2]* 1Department of pharmacy of Peking University third hospital, Beijing, China, and 2The therapeutic drug monitoring and clinical toxicology center of Peking University, Beijing, China and 3Department of Pharmacy of the First Affiliated Hospital of Kunming Medical School, Kunming, China and 4Department of Hematology of Peking University Third Hospital, Beijing, China
P527
UGT1A1 and irinotecan chemotherapy in Azores Islands, Portugal
Paula R. Pacheco1,2, Lisa Esteves1, Maria J Brilhante1, Tânia Pereirinha1, Rita Cabral1,2, Claudia C. Branco1,2 and Luisa Mota-Vieira1,2 1Molecular Genetics and Pathology Unit, Hospital of Divino Espirito Santo of Ponta Delgada, EPE, São Miguel Island, Azores, 2Instituto Gulbenkian de Ciência, Oeiras, Portugal.
P528
Influence of MRP2 haplotype on MPA exposure in kidney transplant patients.
Woillard JB, Levoir L, Rousseau A, Marquet P, Picard N.
Inserm, UMR-S850, Limoges, France, Univ. Limoges, France, CHU Limoges, France.
P529
DISTRIBUTION OF CYP3A5 AND ABCB1 SINGLE NUCLEOTIDE POLYMORPHISMS AND THEIR INFLUENCE ON TACROLIMUS BLOOD LEVELS IN CAUCASIAN KIDNEY TRANSPLANT PATIENTS
Alessio Provenzani1, M. Notarbartolo2, M. Labbozzetta2, P. Poma2, G. Vizzini3, U. Palazzo4, P. Polidori1, F.Triolo5, P. Salis3, C. Caccamo3, T. Bertani3, B. Gridelli6 and N. D’Alessandro2. 1Department of Clinical Pharmacy - ISMETT, 2Department of Pharmacological Sciences “Pietro Benigno” - University of Palermo, 3Department of Medicine - ISMETT, 4Health Direction - ISMETT, 5Regenerative Medicine and Cell Therapy Unit - ISMETT, 6Department of Abdominal Surgery and Transplantation - ISMETT.
P530
Effect of immunosuppressants on CD26/Dipetidyl peptidase IV expression on CD3 cells in vitro.
M. Shipkova, E. Krizan, C. Klett, S. Leicht, E. Wieland. Central Institute for Clinical Chemistry and Laboratory Medicine, Klinikum Stuttgart, Germany.
P531
Association between adverse effects under azathioprine therapy and inosine triphosphate pyrophosphatase (ITPA) activity in patients with chronic inflammatory bowel disease. M. Shipkova1, J. Franz2, M. Abe1, T. Andus2, E. Wieland1. 1Central Inst. for Clin. Chemistry and Lab. Medicine and 2Dept of Internal Medicine, Gastroenterology, Hepatology & Oncology, Klinikum Stuttgart, Germany.
P532
Allele Frequency of the Most Common Polymorphisms of CYP2C9, CYP2C19 and CYP2D6 Genes in a Chilean Population
S. Solari, M. Lagos, H. Poggi, C. Miranda, E. Romeo, P. Engel, JC Ríos. Clinical Laboratory Department, School of Medicine, Pontificia Universidad Católica de Chile. Santiago, Chile.
P533
FREQUENCY OF HLA-B*5701 AS A GENETIC RISK FACTOR FOR ABACAVIR HYPERSENSITIVITY SYNDROME IN A CHILEAN POPULATION
H. Poggi1, M. Lagos1, S. Solari1, A. Vera1, L. Rodríguez1, C. Pérez2.
1Clinical Laboratory and 2Internal Medicine Departments, School of Medicine, Pontificia Universidad Católica de Chile. Santiago, Chile.
P534
Influence of CYP3A5 polymorphism in donor and recipient on tacrolimus pharmacokinetics and clinical outcome after renal transplantation.
Christelle Cauffiez1, François Glowacki2, Arnaud Lionet2, François Provot2, Marc Hazzan2, Christian Noël2, Delphine Allorge1 and Franck Broly1. 1EA2679, Faculté de Médecine/Pôle Recherche, Université de Lille 2, France and 2Pôle de Néphrologie, Hôpital Calmette, CHRU de Lille, France.
P535
UGT1A9 promoter polymorphisms are associated with low MPA AUC and with acute rejection in MMF/tacrolimus treated kidney transplant patients
RHN van Schaik1, M van Agteren1, JW de Fijter2, A Hartman3, J Schmidt4, K Budde5, D Kuypers6, Y Le Meur7, M van der Werf1, R Mamelok8, T van Gelder1
1Erasmus University Medical Centre Rotterdam and 2Leiden University Medical Centre, The Netherlands, 3University of Oslo, Norway; 4University of Heidelberg, Germany; 5Charite University Berlin, Germany; 6University of Leuven, Belgium; 7Central University Hospital Dupuytren, Limoges, France; 8Mamelok Consulting, Palo Alto, CA, USA.
P536
Cytochrome P450-2D6 genotype and pharmacokinetic changes during pregnancy
T. Ververs1, H.A.M. Voorbij1, P. Swarts2 , S.V. Belitser3, A.C.G. Egberts1,3, R.H. van Schaik4, G.H.A. Visser5, A.F.A.M. Schobben1,3 1Dept of Clinical Pharmacy, Division of Laboratory and Clinical Pharmacy, University Medical Center, Utrecht, 2Dept of Psychiatry, Bronovo Hospital, Den Hague, 3Dept of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, 4Dept of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, 5Dept of Perinatology and Gynaecology, University Medical Centre Utrecht, The Netherlands.
P537
Population Pharmacokinetics and Pharmacogenetics of Tacrolimus in de Novo Pediatric Kidney Transplant Recipients
Wei Zhao1 Valéry Elie1 Gwenaelle Roussey3 Karine Brochard4 Patrick Niaudet5 Georges Deschênes6 Pierre Cochat7 Sylvie Cloarec8 Jean Luc André9 Michel Tsimaratos10 Albert Bensman11 May Fakhoury1,2 and Evelyne Jacqz-Aigrain1,2
1Department of Pediatric Pharmacology and Pharmacogenetics, 2Clinical Investigation Center (CIC) 9202, Hôpital Robert Debré, Paris, Departments of Paediatric Nephrology : 3Hôpital Mère et Enfant, Nantes, 4Hôpital des Enfants, Toulouse, 5Hôpital Necker-Enfants Malades, Paris, 6Hôpital Robert Debré, Paris, 7Hôpital Edouard Hériot, Lyon , 8Hôpital Clocheville, Tours, 9Hôpital des Enfants, Nancy, 10Hôpital de la Timone Enfants, Marseille, 11Hôpital Trousseau, Paris, France
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11th International Congress of
